FLuid Optimisation in Emergency LAparotomy Trial

FLO-ELA is the FLuid Optimisation in Emergency LAparotomy trial. It is a large pragmatic clinical trial which aims to find out whether cardiac-output guided haemodynamic therapy given to patients during and shortly after emergency bowel surgery could save lives, when compared with usual care. The trial is being run in 100 UK hospitals and will study nearly 8000 patients.

This project is funded by the National Institute for Health Research Health Technology Assessment programme (project number 15/80/54).


We understand that all site teams need to focus on direct clinical care during COVID-19,
so we are temporarily pausing recruitment to the trial at all sites.

Please stop screening and recruiting patients with immediate effect.

Any patients who have already been consented to participate in the trial but have not yet
undergone surgery may still be included before Monday 23rd March at 09:00.
After this time the randomisation system will be suspended.

We plan to re-start recruitment when site teams have the capacity and we will continue to
update you with revised timelines in due course.

We would like to take this opportunity to thank all of you for your ongoing support for the trial,
and wish you all the best for the challenges ahead.

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