Co-enrol

Studies eligible for co-enrolment with FLO-ELA:

  • A-STOP Trial

    A multi-centre, prospective, diagnostic test accuracy study to assess the performance of three commercially available rapid tests for Candida infection (beta-D-glucan and two PCR-based tests) in the UK critical care setting.
    ISRCTN: 43895480

  • ADAPT-Sepsis Trial

    A randomised controlled, single-blinded, multi-centre trial aiming to determine whether treatment protocols based on monitoring daily CRP (C-reactive protein) or PCT (procalcitonin) safely allow a reduction in duration of antibiotic therapy in hospitalised adult patients with suspected sepsis.
    ISRCTN: 47473244

  • Add-Aspirin Trial

    A phase III, double-blind, placebo-controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumour.
    ISRCTN: 74358648

  • A2B Trial

    A randomised, parallel-group, allocation concealed, controlled, phase 3 trial to determine whether the alpha-2 agonists, clonidine or dexmedetomidine (or both) are clinically cost effective in mechanically ventilated ICU patients compared to current usual care.
    ClinicalTrials.gov Identifier: NCT03653832

  • CReST2

    A blinded, multi-centre randomised controlled trial to compare the effect of uncovered and covered stents on the quality of life of people with inoperable obstructing colorectal cancer who are managed by undertaking an urgent decompression and stenting.
    ISRCTN: 54834267

  • HMB-ICU

    A double blind, placebo controlled, randomised controlled trial to investigate the effect of β-Hydroxy-β-Methylbutyrate (HMB) on skeletal muscle wasting in early critical illness.
    ClinicalTrials.gov Identifier: NCT03464708

  • PEPTIC

    A large, multi-centre, cluster cross over, randomised registry trial comparing the safety and efficacy of proton pump inhibitors with histamine-2 receptor blockers for ulcer prophylaxis in intensive care patients.

  • PQIP

    Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme.

  • PREVENTT Trial

    A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgery.
    ISRCTN: 67322816

  • PRISM Trial

    An international, multi-centre, pragmatic, randomised controlled trial with open study group allocation, to determine if routine continuous positive airway pressure (CPAP) for four hours immediately after major abdominal surgery is effective prophylaxis against postoperative pneumonia, re-intubation or death.
    ISRCTN: 56012545

  • REST Trial

    A pragmatic randomised controlled trial to determine whether Extracorporeal Carbon Dioxide Removal (VV-ECCO2R) and lower tidal volume mechanical ventilation in patients with hypoxaemic respiratory failure improves 90 day mortality.
    ClinicalTrials.gov Identifier: NCT02654327

  • ROSSINI 2

    A multi-arm, multi-stage (MAMS) pragmatic, multicentre, randomised controlled trial, with an internal pilot determining whether three specific in-theatre interventions, alone or in combination, result in decreased rates of surgical site infection (SSI) up to 30 days post operation in adult patients undergoing abdominal surgery.
    ISRCTN: 78305317

  • STRESS-L Trial

    A randomised trial to assess whether the addition of a beta blocker infusion (landiolol) to standard treatment in patients with septic shock, requiring prolonged (>24 hours) support with high-dose vasopressor agents, improves organ failure.
    ISRCTN: 12600919

  • SUNRISE

    Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy. An RCT to determine if the use of a SUNPD in adult patients undergoing emergency laparotomy reduces surgical site infection (SSI) at 30 days compared to surgeon’s preference of dressing.
    ISRCTN: 17599457

  • VACIRISS Trial

    Pneumococcal Vaccination to accelerate Immune Recovery in Sepsis Survivors: randomized placebo-controlled trial.
    ClinicalTrials.gov Identifier: NCT03565159

  • ELF2-Defining the Denominator

    A multicentre prospective cohort study that aims to identify a U.K. consecutive series of older adults presenting with acute abdominal pathology potentially treatable by emergency laparotomy where the decision is made not to undergo surgery (NoLAP) and their associated 90-day mortality

  • REALIST

    This is an open label dose escalation phase 1 trial followed by a randomised, double-blind, placebo-controlled phase 2 trial.
    Clinical Trials.gov IdentifierNCT03042143

Studies NOT eligible for co-enrolment with FLO-ELA:

  • OPTIMISE II Trial

    An international, multi-centre, pragmatic, randomised controlled trial with an open study group allocation, to determine whether cardiac output-guided fluid therapy, with a low dose inotrope infusion is clinically effective when compared to usual care in patients undergoing major gastrointestinal surgery.
    ISRCTN: 39653756

  • 65 Trial

    Evaluating the clinical and cost effectiveness of using a more conservative mean arterial pressure target range to guide careful titration of vasopressors to minimise dose and duration in older critically ill patients with vasodilatory hypotension: the 65 trial.
    ISRCTN: 10580502