Studies eligible for co-enrolment with FLO-ELA:

  • PREVENTT Trial

    A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgery.
    ISRCTN: 67322816

  • PRISM Trial

    An international, multi-centre, pragmatic, randomised controlled trial with open study group allocation, to determine if routine continuous positive airway pressure (CPAP) for four hours immediately after major abdominal surgery is effective prophylaxis against postoperative pneumonia, re-intubation or death.
    ISRCTN: 56012545

  • REST Trial

    A pragmatic randomised controlled trial to determine whether Extracorporeal Carbon Dioxide Removal (VV-ECCO2R) and lower tidal volume mechanical ventilation in patients with hypoxaemic respiratory failure improves 90 day mortality. Identifier: NCT02654327


    A large, multi-centre, cluster cross over, randomised registry trial comparing the safety and efficacy of proton pump inhibitors with histamine-2 receptor blockers for ulcer prophylaxis in intensive care patients.

  • PQIP

    Improving perioperative care through the use of quality data: Patient Study of the Perioperative Quality Improvement Programme.


    Pneumococcal Vaccination to accelerate Immune Recovery in Sepsis Survivors: randomized placebo-controlled trial. Identifier: NCT03565159


    A double blind, placebo controlled, randomised controlled trial to investigate the effect of β-Hydroxy-β-Methylbutyrate (HMB) on skeletal muscle wasting in early critical illness. Identifier: NCT03464708


    Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy. An RCT to determine if the use of a SUNPD in adult patients undergoing emergency laparotomy reduces surgical site infection (SSI) at 30 days compared to surgeon’s preference of dressing.
    ISRCTN: 17599457


    A randomised trial to assess whether the addition of a beta blocker infusion (landiolol) to standard treatment in patients with septic shock, requiring prolonged (>24 hours) support with high-dose vasopressor agents, improves organ failure.
    ISRCTN: 12600919

  • A2B Trial

    A randomised, parallel-group, allocation concealed, controlled, phase 3 trial to determine whether the alpha-2 agonists, clonidine or dexmedetomidine (or both) are clinically cost effective in mechanically ventilated ICU patients compared to current usual care. Identifier: NCT03653832

  • Add-Aspirin Trial

    A phase III, double-blind, placebo-controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumour.
    ISRCTN: 74358648

  • A-STOP

    A multi-centre, prospective, diagnostic test accuracy study to assess the performance of three commercially available rapid tests for Candida infection (beta-D-glucan and two PCR-based tests) in the UK critical care setting.
    ISRCTN: 43895480

Studies NOT eligible for co-enrolment with FLO-ELA:


    An international, multi-centre, pragmatic, randomised controlled trial with an open study group allocation, to determine whether cardiac output-guided fluid therapy, with a low dose inotrope infusion is clinically effective when compared to usual care in patients undergoing major gastrointestinal surgery.
    ISRCTN: 39653756

  • 65 Trial

    Evaluating the clinical and cost effectiveness of using a more conservative mean arterial pressure target range to guide careful titration of vasopressors to minimise dose and duration in older critically ill patients with vasodilatory hypotension: the 65 trial.
    ISRCTN: 10580502